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From October 2017 to March 2018,398 patients with acute ischemic stroke admitted in Department of Neurology,First Hospital of Shanxi Medical University were enrolled in the study,including 59 cases with elevated troponin (cTn) and 339 cases with normal cTn level.Patients were assessed with National institute of Health Stroke Scale (NIHSS),Chinese Ischemic Stroke Subclassification (CISS),Island cortical lesions and related non-neurological diseases.The short-term prognosis was assessed by NIHSS score during 10-15 days in hospital and compared between the two groups.Multivariate regression analysis showed that elevated serum cTn was independently associated with insular cortex damage (OR=2.87,95％CI:1.26-6.53),NIHSS score at admission (OR=1.08,95％ CI:1.01-1.14),hemorrhagic transformation (OR=6.71,95％ CI:2.21-20.38),cancer (OR=5.04,95％ CI:1.43-17.77),and the level of serum creatinine (OR=1.02,95％CI:1.01-1.03).Increased serum cTn in acute ischemic stroke is associated with severe neurological deficits,insular cortex damage and non-neurological diseases.Aacute ischemic stroke patients with increased serum troponin have a more severe prognosis.
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Objective To investigate the differences in risk factors for cerebral hemorrhage between urban and rural areas in northern China to provide accurate prevention for cerebral hemorrhage in both urban and rural areas. Methods Data was collected from patients over 40 years old in different provinces in northern China, which was further divided into urban and rural groups. Condition matching method was used to analyze the risk factors and to compare these risk factors between urban and rural cerebral hemorrhage and. Results Data from 191,625 people were collected. Among 559 patients with cerebral hemorrhage, there were 251 and 308 patients in urban and rural areas, respectively Hypertension and lack of exercise had a stronger effect on cerebral hemorrhage in rural area [OR 95%CI (9.07,6.25～13.16)vs. (7.67,5.20～11.32)]、 [OR 95% CI (2.18,1.59～2.98)vs. (1.89,1.36～2.62)]. Family history of stroke, diabetes, and excessive overweight had bigger impacts on urban cerebral hemorrhage [OR 95%CI(5.40,3.48～8.36)vs.(5.09,3.37～7.68)]、[OR 95%CI(2.41,1.55～3.75)vs.(1.98,1.21～3.23)]、[OR 95%CI(2.38,1.69～3.35)vs.(1.71,1.26～2.32)]. Conclusions A more precise preventive measures can be developed based on the impact of different risk factors on urban and rural areas
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Patients with acute ischemic stroke (AIS) often have myocardial damage.Cardiactroponin (cTn) is a sensitive and specific marker of myocardial necrosis,and its level increases significantly in myocardial injury.The related literatures report that the elevated cTn can also be observed in patients with AIS.This article reviews the pathophysiological mechanism and clinical significance of the elevated cTn after
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Objetive To investigate physicians'knowledge regarding intravenous fibrinolytic therapy for acute ischemic stroke and whether their hospitals could meet the requirements for the therapy. Methods Questionnaires were mailed to 500 physicians from 153 hospitals in Shanxi including 112 secondary and 41 tertiary hospitals. 370 physicians returned valid questionnaires. Results One hundred thirty-four hospitals (87.6%) could provide 24-hour computed to?mography service, including 95 (84.8%) secondary hospitals and 39 (95.1%) tertiary hospitals. Alteplase stock was avail?able in 59 hospitals (38.6%), containing 25 (22.3%) secondary and 34 (82.9%) tertiary hospitals. Accuracy rates of 13 questions regarding intravenous fibrinolytic therapy for acute ischemic stroke ranged from 30.8% to 82.9%. Accuracy rates of 6 questions were lower than 50.0%. Conclusions The present study has revealed that physicians in this study have poor knowledge regarding the therapy. The situation can not meet the demand of healthcare, which partially ac?counts for the low rate in fibrinolytic therapy in Shanxi. Relevant training and suitable assessment should be carried out compulsively to ensure that physicians grasp necessary knowledge and skills.
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Objectives To screen the high-risk population of stroke in China using color Doppler flow imaging (CDFI)and to establish a stroke risk prediction model in Chinese population in order to prevent and treat stroke early. Methods Forty-one base hospitals and 715 286 people in the project areas of the first 6 provinces of China conducted routine physical examinations and investigated the related risk factors for cardiocerebrovascular diseases from July 2011 to April 2012 using a cross-sectional study,among them 61 860 patients underwent carotid CDFI screening,and 49 386 of them were high-risk population (exposed to≥3 risk factors). The bilateral common carotid interma-media thickness (IMT),the number of plaques and the degree of carotid stenosis were screened and documented. And whether carotid IMT thickening or not,with or without carotid plaques,and degree of carotid artery stenotic rate 0-49% and≥50% were performed by multivariate logistic regression analysis with the risk factors for stroke,respectively. Results (1)Logistic regression analysis showed that hypertension,atrial fibrillation,smoking,and lack of physical exercise were the independent risk factors for carotid IMT thickening (hypertension:OR,1. 17;95%CI 1. 12-1. 22;atrial fibrillation:OR,1. 15;95%CI 1. 09-1. 21;smoking:OR,1. 13;95%CI 1. 08-1. 17;and lack of physical exercise:OR,1. 12;95%CI 1.08-1. 16). (2)Hypertension,atrial fibrillation, smoking,and diabetes were the independent risk factors for carotid plaque and carotid artery stenosis rate≥50%(carotid plaque,hypertension:OR,1. 55;95%CI 1. 47-1. 62;atrial fibrillation:OR,1. 13;95%CI 1.06-1. 21;smoking:OR,1. 16;95%CI 1. 11-1. 22;and diabetes:OR,1. 30;95%CI 1. 24-1. 37). Carotid stenosis rate≥50%,hypertension:OR,1. 78;95%CI 1.55-2. 03;atrial fibrillation:OR,1. 59;95%CI 1. 39-1. 81;smoking:OR,1. 33;95%CI 1. 20-1. 48;and diabetes:OR,1. 30;95%CI 1. 17-1. 45. Simple obesity did not increase the incidences of carotid atherosclerotic plaque and carotid artery stenosis ≥50%(OR,0. 78, 0.83;95%CI 0. 75-0. 82 ,0. 75-0. 92,respectively). Conclusions Neck vascular ultrasound can be used as a valuable means for screening high-risk population and detecting risk factors of stroke. It has an important clinical significance for the early diagnosis and treatment of carotid atherosclerosis disease.
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n he found for the treatment of ischemic cerebrovas-cular disease. This article reviews the recent progress in research on cerebral ischemia-reperfusion-induced ERS.
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@#Reversible cerebral vasoconstriction syndrome (RCVS) usually occurs during normal pregnancy or a few days after delivery. The gold standard of diagnosis is the reversibility of cerebral vascular constriction confirmed by digital subtraction angiography (DSA). In this article, we descried the clinical and imaging features of one RCVS case proved by repeating DSA, and discussed the probably pathophysiological mechanisms.
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In recent years, with the development of neuroimaging and the advancement in related studies, people have had a deeper understanding of perimesencephalic nonaneurysmal subarachnoid hemorrhage. This article reviews the progress in research on the etiology, onset characteristics, imaging features, diagnosis and prognosis of perimesencephalic nonaneurysmal subarachnoid hemorrhage.
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Although thrombolytic therapy is the only method recommended by the Food and Drug Administration(FDA)for acute ischemic stroke,the time window limits its application.Thus,neuroprotective research,which has a wider application become the focus.This article summarizes the neruoprotective methods in animal researches and clinical trials.
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0.8 mm) of carotid artery in patient group (42.3%) were more than those in control group (7.4%)((P45 yrs).Conclusion Cerebral infarction in young and middle-aged patients is closely related to atherosclerosis of carotid artery.